Publications

10. Anlas A.A., Sprenger, M., Wang, M., Hayes, B.H., Phan, S., Discher, D.E. (2025) Matrix stiffness suppresses growth, induces chromosome missegregation and genomic variation in cancer spheroids. In revision at PNAS. Biorxiv: https://doi.org/10.1101/2025.01.28.635370

9. Anlas A.A. (2025) Micromanaging the Nuclear Lamina. Biophysical Journal. https://doi.org/10.1016/j.bpj.2025.06.003

8. Dooling L.J, Anlas A.A., Tobin M.P., Ontko N., Marchena T., Wang M., Andrechak J., Discher D.E. (2024) Clustered macrophages cooperate to eliminate tumors via coordinated intrudopodia. PNAS. https://doi.org/10.1073/pnas.2425452122

7. Anlas A.A. and Nelson C.M. (2024) Interplay between hormonal and mechanical signals in mammary morphodynamics. Trends in Cell Biology. https://doi.org/10.1016/j.tcb.2024.03.004

6. Zhu, K., Hayes, B., Wang, M., Pfeifer, C., Xia, Y., Andrechak, J., Du, J., Tobin, M., Anlas, A.A., Dooling L., Vashisth, M., Irianto, J., Lampson M.A., Discher, D.E. (2023), 3D stiffness plus Myosin-II suppression maximizes heritable chromosome losses as revealed by live-cell ChReporters. Journal of Cell Science. https://doi.org/10.1242/jcs.260753

5. Dooling L., Saini K. Anlas A. A., Discher D.E. (2022) Tissue mechanics coevolves with fibrillar matrisomes in healthy and fibrotic tissues. Matrix Biology. 111: 153-188. https://doi.org/10.1016/j.matbio.2022.06.006

4. Anlas A.A. and Nelson C.M. (2020) Living under strain: how epithelia protect their genomes from repeated stretching. Biochemistry, 4:2761-2763. https://doi.org/10.1021/acs.biochem.0c00545

3. Anlas A.A. and Nelson C.M. (2020) Soft microenvironments induce chemoresistance by increasing autophagy downstream of integrin-linked kinase. Cancer Research, 80:4103-4113. https://doi.org/10.1158/0008-5472.CAN-19-4021

2. Anlas A.A. Nelson C.M. (2018) Tissue mechanics regulates form, function, and dysfunction. Curr. Opin. Cell Biol., 54: 98-105. https://doi.org/10.1016/j.ceb.2018.05.012

1. Simi A.K., Anlas A.A., Stallings-Mann M., Zhang S., Hsia T., Cichon M., Radisky D.C., Nelson C.M. (2018) A soft microenvironment protects from failure of midbody abscission and multinucleation downstream of the EMT-promoting transcription factor Snail. Cancer Research, 78: 2277-2289. https://doi.org/10.1158/0008-5472.CAN-17-2899

In preparation:

Anlas A.A. and Kurt M., Engineering Mechanointelligence, a review article on artificial intelligence in mechanobiology research in collaboration with Mehmet Kurt (UW).